Bioinformatics and Data Analysis

Now analysis is of two kinds, the one directed to searching for the truth and called theoretical, the other directed to finding what we are told to find and called problematical. (1) In the theoretical kind we assume what is sought as if it were existent and true, after which we pass through its successive consequences, as if they too were true and established by virtue of our hypothesis, to something admitted: then (a), if that something admitted is true, that which is sought will also be true and the proof will correspond in the reverse order to the analysis, but (b), if we come upon something admittedly false, that which is sought will also be false. (2) In the problematical kind we assume that which is propounded as if it were known, after which we pass through its successive consequences, taking them as true, up to something admitted: if then (a) what is admitted is possible and obtainable, that is, what mathematicians call given, what was originally proposed will also be possible, and the proof will again correspond in reverse order to the analysis, but if (b) we come upon something admittedly impossible, the problem will also be impossible.

The investigation of difficult things by the method of analysis ought ever to precede the method of composition.

[A]t the close of the Middle Ages, when the so-called Arabic figures became established throughout Europe with the symbol 0 and the principle of local value, immediate progress was made in the art of reckoning. The problems... led up to the general solutions of equations of the third and fourth degree by the Italian mathematicians of the sixteenth century. Yet even these discoveries were made in somewhat the same manner as problems in mental arithmetic are now solved in common schools; for the present signs of plus, minus, and equality, the radical and exponential signs, and especially the systematic use of letters for denoting general quantities in algebra, had not yet become universal. The last step was definitively due to... Vieta... and the mighty advancement of analysis resulting therefrom can hardly be measured or imagined.